Table 1. List of significant deregulated pathways in cell lines obtained using IPA.
| TF1 | SKM1 | K562 | HEL |
|---|---|---|---|
| Selenoamino acid metabolism | Estrogen-mediated S-phase entry | AMPK signaling | Estrogen-mediated S-phase entry |
| Mitochondrial dysfunction | Pentose phosphate pathway | HMGB1 signaling | Cyclins and cell cycle regulation |
| AMPK signaling | Cell cycle: G1/S checkpoint regulation | mTOR signaling | PI3K signaling in B lymphocytes |
| Regulation of eIF4 and p70S6K signaling | Small-cell lung cancer signaling | Polyamine regulation in colon cancer | mTOR signaling |
| mTOR signaling | Lysine biosynthesis | Cell cycle regulation by BTG family proteins | Breast cancer regulation by stathmin1 |
| Role of NANOG in mammalian embryonic stem cell pluripotency | Actin cytoskeleton signaling | ILK signaling | Purine metabolism |
| Cyclins and cell cycle regulation | Chronic myeloid leukemia signaling | Cyclins and cell cycle regulation | Glioma signaling |
| Polyamine regulation in colon cancer | Glioma signaling | Ceramide signaling | Aldosterone signaling in epithelial cells |
| Assembly of RNA polymerase II complex | Assembly of RNA polymerase III complex | ErbB signaling | fMLP signaling in neutrophils |
| Signaling by Rho family GTPases | TNFR1 signaling | Cell cycle: G1/S checkpoint regulation | |
| Glucocorticoid receptor signaling | Non-small cell lung cancer signaling | ||
| Glycine, serine and threonine metabolism | Growth hormone signaling | ||
| Role of CHK proteins in cell cycle checkpoint control | Small-cell lung cancer signaling | ||
| VDR/RXR activation | Protein ubiquitination pathway | ||
| Lysine degradation | Nitric oxide signaling in the cardiovascular system | ||
| Tight junction signaling | AMPK signaling | ||
| Ubiquinone biosynthesis | Glioblastoma multiforme signaling | ||
| Mitotic roles of polo-like kinase | |||
| Wnt/β-catenin signaling | |||
| PI3K/AKT signaling | |||
| Renal cell carcinoma signaling | |||
| Regulation of eIF4 and p70S6K signaling | |||
| TNFR2 signaling | |||
| Fructose and mannose metabolism | |||
| Telomerase signaling |
Gene expression profiling was performed in all four cell lines with SF3B1 knockdown, and genes showing >2-fold change were used for the analysis.