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. 2014 Dec 23;29(5):1092–1103. doi: 10.1038/leu.2014.331

Table 3. Pathway analysis (IPA) of the significant differentially expressed genes between SF3B1 mutant and wild type obtained using edgeR.

Ingenuity canonical pathways P-value Ratio Molecules
Lymphotoxin β receptor signaling 0.00074131 9.68E−02 NFKBID, BCL2L1, CASP3, RELB, CXCL1 and TRAF1
Agranulocyte adhesion and diapedesis 0.001071519 5.73E−02 CXCL3, PODXL2, CCL4,CLDN19, CXCL14, CXCL1, CCL3L1/CCL3L3, MMP2, CXCL2, MYH7B and CCL4L1/CCL4L2
Heme biosynthesis II 0.001096478 1.67E−01 FECH, ALAS2, CPOX and HMBS
Hepatic fibrosis/hepatic stellate cell activation 0.00162181 5.81E−02 CXCL3, LEPR, IL6R, MMP2, LBP, IL6, MYH7B, AGTR1 and PGF
Communication between innate and adaptive immune cells 0.001995262 6.25E−02 CCL4, TLR7, CCL3L1/CCL3L3, CD83, IGHG1, IGHA1 and IL6
Colorectal cancer metastasis signaling 0.003467369 4.48E−02 BCL2L1, ADCY9, CDH1, JUN, CASP3, PTGER3, DIRAS3, IL6R, TLR7, MMP2, IL6 and PGF
IL-17A signaling in fibroblasts 0.004570882 1E−01 NFKBID, JUN, IL6 and NFKBIZ
Toll-like receptor signaling 0.004570882 7.81E−02 JUN, TLR7, TNFAIP3, LBP and TRAF1
Differential regulation of cytokine production in macrophages and T-helper cells by IL-17A and IL-17F 0.004786301 1.67E−01 CCL4, CXCL1 and IL6
Granulocyte adhesion and diapedesis 0.007762471 4.95E−02 CXCL3, CCL4, CLDN19, CXCL14, CXCL1, CCL3L1/CCL3L3, MMP2, CXCL2 and CCL4L1/CCL4L2
Airway pathology in chronic obstructive pulmonary disease 0.009772372 1.82E−01 CXCL3 and MMP2
TNFR2 signaling 0.016595869 8.82E−02 JUN, TNFAIP3 and TRAF1
Heme bosynthesis from uroporphyrinogen-III I 0.018620871 1.82E−01 FECH and CPOX
Aryl hydrocarbon receptor signaling 0.024547089 4.09E−02 TGM2, CCNE1, GSTM2, ALDH1A1, JUN, NQO2 and IL6
NRF2-mediated oxidative stress response 0.025118864 4.1E−02 GSR, JUN, GSTM2, NQO2, DNAJC6, JUND, FOSL1 and ABCC4
Role of IL-17A in psoriasis 0.025703958 1.43E−01 CXCL3 and CXCL1
Gα12/13 signaling 0.028840315 4.72E−02 BTK, CDH7, CDH1, JUN, MEF2D and CDH11
Tetrapyrrole biosynthesis II 0.029512092 1.43E−01 ALAS2 and HMBS
CDK5 signaling 0.033884416 5.15E−02 FOSB, PPP1CC, ADCY9, PPM1J and EGR1
CD40 signaling 0.033884416 5.63E−02 JUN, TNFAIP3, MAPKAPK2 and TRAF1
Mitotic roles of polo-like kinase 0.041686938 5.41E−02 PLK3, PPM1J, ANAPC13 and CCNB1
Adenine and adenosine salvage III 0.042657952 1.18E−01 PNP and ADAT3
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 0.046773514 1.11E−01 HAAO and KYNU
T-helper cell differentiation 0.047863009 5.56E−02 STAT4, IL6R, IL6 and RORC