Table 4. Top ranking genes showing differential exon usage between SF3B1 mutant and control, obtained from RNA sequencing data analysis using DEXSeq.
| Gene ID | Exon ID | Gene name | Chromosome | Strand | P-value | Padj | FC |
|---|---|---|---|---|---|---|---|
| ENSG00000125354 | E011 | SEPT6 | X | −1 | 1.67E−78 | 5.19E−73 | 0.822522658 |
| ENSG00000111843 | E006 | TMEM14C | 6 | 1 | 2.80E−51 | 4.36E−46 | 0.803897136 |
| ENSG00000131669 | E006 | NINJ1 | 9 | −1 | 1.09E−33 | 1.13E−28 | 0.835812796 |
| ENSG00000088986 | E014 | DYNLL1 | 12 | 1 | 1.21E−28 | 9.43E−24 | 0.913566493 |
| ENSG00000223865 | E018 | HLA-DPB1 | 6 | 1 | 3.05E−27 | 1.90E−22 | 1.357267219 |
| ENSG00000101019 | E025 | UQCC1 | 20 | −1 | 1.71E−26 | 8.88E−22 | 0.889537433 |
| ENSG00000132199 | E025 | ENOSF1 | 18 | −1 | 2.57E−24 | 1.14E−19 | 0.905515696 |
| ENSG00000125991 | E049 | ERGIC3 | 20 | 1 | 4.11E−23 | 1.42E−18 | 0.870728412 |
| ENSG00000101019 | E024 | UQCC1 | 20 | −1 | 2.01E−22 | 6.25E−18 | 0.878172451 |
| ENSG00000118495 | E010 | PLAGL1 | 6 | −1 | 2.78E−22 | 7.85E−18 | 1.753766932 |
| ENSG00000266086 | E005 | RP11-159D12.5 | 17 | −1 | 1.43E−18 | 3.43E−14 | 1.051487592 |
| ENSG00000119777 | E023 | TMEM214 | 2 | 1 | 1.35E−18 | 3.43E−14 | 0.724952987 |
| ENSG00000130066 | E011 | SAT1 | X | 1 | 2.63E−17 | 5.83E−13 | 1.224469811 |
| ENSG00000101019 | E029 | UQCC1 | 20 | −1 | 3.49E−17 | 7.24E−13 | 0.987866168 |
| ENSG00000141425 | E015 | RPRD1A | 18 | −1 | 2.14E−16 | 3.91E−12 | 1.151614234 |
| ENSG00000268400 | E058 | CTD-3214H19.4 | 19 | 1 | 2.08E−16 | 3.91E−12 | 0.720165623 |
| ENSG00000127586 | E055 | CHTF18 | 16 | 1 | 2.45E−16 | 4.24E−12 | 0.83461565 |
| ENSG00000130066 | E015 | SAT1 | X | 1 | 4.80E−16 | 7.86E−12 | 1.112053709 |
| ENSG00000160789 | E072 | LMNA | 1 | 1 | 1.00E−15 | 1.56E−11 | 0.74131183 |
| ENSG00000130066 | E010 | SAT1 | X | 1 | 1.22E−15 | 1.81E−11 | 1.175909464 |
| ENSG00000119777 | E024 | TMEM214 | 2 | 1 | 6.13E−15 | 8.66E−11 | 0.769414939 |
| ENSG00000266086 | E004 | RP11-159D12.5 | 17 | −1 | 1.51E−14 | 2.04E−10 | 1.073999383 |
| ENSG00000168675 | E009 | LDLRAD4 | 18 | 1 | 4.10E−14 | 5.10E−10 | 0.882283199 |
| ENSG00000160789 | E071 | LMNA | 1 | 1 | 6.34E−14 | 7.58E−10 | 0.907377148 |
| ENSG00000214021 | E019 | TTLL3 | 3 | 1 | 1.13E−13 | 1.30E−09 | 1.027729333 |
| ENSG00000196576 | E041 | PLXNB2 | 22 | −1 | 1.59E−13 | 1.77E−09 | 0.53703246 |
| ENSG00000166508 | E021 | MCM7 | 7 | −1 | 2.21E−13 | 2.37E−09 | 1.034956343 |
| ENSG00000114770 | E040 | ABCC5 | 3 | −1 | 2.75E−13 | 2.79E−09 | 1.290748901 |
| ENSG00000196365 | E028 | LONP1 | 19 | −1 | 2.78E−13 | 2.79E−09 | 0.876937237 |
| ENSG00000130066 | E002 | SAT1 | X | 1 | 3.59E−13 | 3.49E−09 | 0.967812734 |
| ENSG00000102119 | E017 | EMD | X | 1 | 3.76E−13 | 3.55E−09 | 1.050545479 |
| ENSG00000130066 | E014 | SAT1 | X | 1 | 5.55E−13 | 5.08E−09 | 1.168469304 |
| ENSG00000266086 | E006 | RP11-159D12.5 | 17 | −1 | 5.72E−13 | 5.08E−09 | 1.073091463 |
| ENSG00000055609 | E005 | KMT2C | 7 | −1 | 6.09E−13 | 5.26E−09 | 1.089688525 |
| ENSG00000228315 | E065 | GUSBP11 | 22 | −1 | 6.70E−13 | 5.63E−09 | 1.125912723 |
| ENSG00000156860 | E023 | FBRS | 16 | 1 | 7.27E−13 | 5.95E−09 | 1.10075677 |
| ENSG00000268400 | E071 | CTD-3214H19.4 | 19 | 1 | 8.37E−13 | 6.67E−09 | 1.139015436 |
| ENSG00000214021 | E065 | TTLL3 | 3 | 1 | 1.15E−12 | 8.34E−09 | 1.269221488 |
| ENSG00000122566 | E004 | HNRNPA2B1 | 7 | −1 | 1.10E−12 | 8.34E−09 | 1.160615984 |
| ENSG00000101557 | E035 | USP14 | 18 | 1 | 1.13E−12 | 8.34E−09 | 1.043528763 |
Genes are ranked by adjusted P-value (Padj).