Table 5. Top ranking genes showing differential exon usage between SF3B1 mutant and wild type, obtained from RNA sequencing data analysis using DEXSeq.
| Gene ID | Exon ID | Gene name | Chromosome | Strand | P-value | Padj | FC |
|---|---|---|---|---|---|---|---|
| ENSG00000125354 | E011 | SEPT6 | X | −1 | 9.38E−92 | 3.53E−86 | 0.827252395 |
| ENSG00000132199 | E025 | ENOSF1 | 18 | −1 | 5.10E−33 | 9.59E−28 | 0.911519852 |
| ENSG00000189283 | E004 | FHIT | 3 | −1 | 1.73E−28 | 2.18E−23 | 3.663047029 |
| ENSG00000101019 | E025 | UQCC1 | 20 | −1 | 9.24E−28 | 8.69E−23 | 0.72317914 |
| ENSG00000111843 | E006 | TMEM14C | 6 | 1 | 9.84E−26 | 7.40E−21 | 0.91596329 |
| ENSG00000125991 | E049 | ERGIC3 | 20 | 1 | 9.81E−23 | 6.15E−18 | 0.791616483 |
| ENSG00000071082 | E025 | RPL31 | 2 | 1 | 3.50E−21 | 1.88E−16 | 0.717351893 |
| ENSG00000101019 | E029 | UQCC1 | 20 | −1 | 2.62E−20 | 1.23E−15 | 0.701671242 |
| ENSG00000211644 | E016 | IGLV1-51 | 22 | 1 | 3.99E−20 | 1.67E−15 | 0.441359946 |
| ENSG00000088986 | E014 | DYNLL1 | 12 | 1 | 5.65E−20 | 2.12E−15 | 0.845893878 |
| ENSG00000028310 | E077 | BRD9 | 5 | −1 | 3.97E−18 | 1.36E−13 | 0.767361674 |
| ENSG00000127586 | E055 | CHTF18 | 16 | 1 | 2.12E−17 | 6.64E−13 | 0.878313474 |
| ENSG00000101019 | E007 | UQCC1 | 20 | −1 | 3.20E−17 | 9.25E−13 | 1.47227241 |
| ENSG00000160710 | E024 | ADAR | 1 | −1 | 1.30E−16 | 3.51E−12 | 1.320985378 |
| ENSG00000101019 | E024 | UQCC1 | 20 | −1 | 2.02E−16 | 5.06E−12 | 0.71746253 |
| ENSG00000118495 | E010 | PLAGL1 | 6 | −1 | 4.10E−16 | 9.65E−12 | 2.538692764 |
| ENSG00000255863 | E017 | AC073610.5 | 12 | −1 | 1.20E−15 | 2.65E−11 | 0.882954589 |
| ENSG00000211644 | E017 | IGLV1-51 | 22 | 1 | 1.38E−15 | 2.88E−11 | 0.485819764 |
| ENSG00000075218 | E014 | GTSE1 | 22 | 1 | 2.48E−15 | 4.91E−11 | 1.468605485 |
| ENSG00000137133 | E004 | HINT2 | 9 | −1 | 2.09E−14 | 3.93E−10 | 0.839329231 |
| ENSG00000205593 | E031 | DENND6B | 22 | −1 | 5.28E−14 | 9.46E−10 | 4.609575952 |
| ENSG00000101019 | E013 | UQCC1 | 20 | −1 | 1.05E−13 | 1.74E−09 | 2.895712194 |
| ENSG00000101019 | E026 | UQCC1 | 20 | −1 | 1.11E−13 | 1.74E−09 | 0.732192837 |
| ENSG00000101019 | E028 | UQCC1 | 20 | −1 | 1.10E−13 | 1.74E−09 | 0.698206407 |
| ENSG00000103426 | E028 | CORO7-PAM16 | 16 | −1 | 1.21E−13 | 1.83E−09 | 0.838759667 |
| ENSG00000205593 | E030 | DENND6B | 22 | −1 | 3.43E−13 | 4.97E−09 | 4.61396886 |
| ENSG00000101019 | E010 | UQCC1 | 20 | −1 | 4.54E−13 | 6.33E−09 | 1.74387423 |
| ENSG00000111640 | E017 | GAPDH | 12 | 1 | 8.37E−13 | 1.12E−08 | 1.387332969 |
| ENSG00000100387 | E034 | RBX1 | 22 | 1 | 1.24E−12 | 1.61E−08 | 1.875629945 |
| ENSG00000271270 | E006 | TMCC1-AS1 | 3 | 1 | 2.12E−12 | 2.66E−08 | 2.979442225 |
| ENSG00000028310 | E078 | BRD9 | 5 | −1 | 3.00E−12 | 3.64E−08 | 0.795339192 |
| ENSG00000101019 | E027 | UQCC1 | 20 | −1 | 3.26E−12 | 3.84E−08 | 0.703747197 |
| ENSG00000255103 | E077 | KIAA0754 | 1 | 1 | 3.38E−12 | 3.85E−08 | 1.663519412 |
| ENSG00000268400 | E035 | CTD-3214H19.4 | 19 | 1 | 3.57E−12 | 3.95E−08 | 1.463054031 |
| ENSG00000205593 | E032 | DENND6B | 22 | −1 | 4.28E−12 | 4.60E−08 | 4.764064117 |
| ENSG00000136044 | E042 | APPL2 | 12 | −1 | 5.63E−12 | 5.88E−08 | 0.720698938 |
| ENSG00000101019 | E005 | UQCC1 | 20 | −1 | 1.00E−11 | 9.92E−08 | 1.53637968 |
| ENSG00000167323 | E043 | STIM1 | 11 | 1 | 9.97E−12 | 9.92E−08 | 0.766910234 |
| ENSG00000101019 | E016 | UQCC1 | 20 | −1 | 1.35E−11 | 1.28E−07 | 2.2692562 |
| ENSG00000161013 | E025 | MGAT4B | 5 | −1 | 1.36E−11 | 1.28E−07 | 1.097105348 |
Genes are ranked by adjusted P-value (Padj).