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. 2015 Apr 9;13:320–328. doi: 10.1016/j.csbj.2015.03.006

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© 2015 Ibrahim. Published by Elsevier B.V. on behalf of the Research Network of Computational and Structural Biotechnology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Spatial simulation of APC and Cdc20 dynamics. The figures show the total concentrations over time for free APC and free Cdc20. All results are presented for 10⁸ M^− 1 s^− 1 value of the APC/C binding rates (k₅, k₆ and k₈). We can clearly see that only for the MCC–BubR1 model variant that binds second Cdc20, complete APC and Cdc20 sequestration is achieved.