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. 2015 Apr 9;13:320–328. doi: 10.1016/j.csbj.2015.03.006

Table 2.

In-silico mutation experiments for validation.

3.3.

D refers to deletion or knockdown experiment, and O refers to an over-expression experiment. Failed to arrest means very high level of [APC:Cdc20] and low sequestration level of Cdc20. Arrested means very low level of [APC:Cdc20] and fully sequestration of Cdc20. Green means fully consistent with experiments and capture the desire behavior. Yellow means consistent with experiments but required specific MCC–APC binding rate (see text for details).