Figure 2.

Structure of the MBCSIM simulation model for the FES-PET/CT strategy. Women enter the simulation with bone, lung, liver and/or brain symptoms. The triangles indicate questions with output indicators Y=yes and N=no. The squares indicate imaging tests with output indicators, + denotes positive, − denotes negative and ± denotes inconclusive. In case of multimodality imaging (i.e., FES-PET and CT), each individual modality can have these three outcomes, leading to nine possible outcomes for the combined modality (i.e., FES-PET/CT).