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. 2015 May;3(7):95. doi: 10.3978/j.issn.2305-5839.2015.03.57

Figure 2.

Figure 2

Virtual karyotype generated from a SNP array by chromosome analysis suite freeware. (A) Chromosome analysis suite virtual karyotype of a patient with GBM who had tissue sent for SNP array analysis. Classical findings of Chr 10 loss and 7 gain are identified with novel focal amplifications of Chr 12 (B) of GLI1 and (C) CDK4. This unique genomic profile is the signature of a classical GBM with new therapeutic targets in GLI/CDK4/6. Similar analysis can be carried out on high grade gliomas to help with diagnosis when histology is equivocal and aid in determining prognosis. GBM, glioblastomas.