Table 2. Review of glioma markers that aid in diagnosis and prognosis of diffuse gliomas—utility of glioma markers and methods of assessment.
| Marker | Diagnosis | WHO Grade | Prognosis | IHC | FISH | PCR/SNP |
|---|---|---|---|---|---|---|
| IDH1/2 | Glioma; 20 GBM | WHO > II | Progression free survival >5 years | Yes | No | Yes |
| 1p19q | Oligodendroglioma | WHO > II | Progression free survival >5 years | No | Yes | Yes |
| MGMT | No diagnostic role | WHO III-IV | Improved response to TMZ | No | No | Yes |
| +7/+10 | 10 GBM; progression | WHO III-IV | Poor | No | No | Yes |
WHO, World Health Organization; IHC, immunohistochemistry; PCR, polymerase chain reaction; MGMT, O6-methyl-guanine-DNA methyltransferase; TMZ, temozolamide.