Table 4. Stratification scheme for high grade lesions based on current data regarding IDH mutational status and the presence or absence of copy number abnormalities associated with chromosomes 7 and 10—WHO III anaplastic glioma stratification with prognosis.
Types | +7 | +7/-10q |
---|---|---|
IDH1/2 mutation | Anaplastic astrocytoma: survival >5 years | Anaplastic oligodendroglioma: survival >10 years |
IDH wild type | Anaplastic astrocytoma: progression to 20 GBM <2 years | 20 GBM: survival <2 years |
WHO, World Health Organization.