Table 2. Acute (day 1) amphetamine-related effects on subjective-effect ratings.
| Drug conditions | |||||||
|---|---|---|---|---|---|---|---|
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| Placebo | 20 mg MA | 40 mg MA | 100 mg MDMA | ||||
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| Mean (SEM) | Mean (SEM) | F value | Mean (SEM) | F value | Mean (SEM) | F value | |
| Peak physiological and “positive” subjective-effect ratings | |||||||
| Alert | 28.0 (9.1) | 55.3 (9.6) | 18.2* | 61.5 (9.2) | 27.6* | 34.6 (9.0) | 10.4§† |
| Blurred vision | 0.0 (0.0) | 3.2 (2.5) | 1.1 | 6.5 (3.7) | 4.7 | 27.2 (9.8) | 81.8*§† |
| Chills | 0.0 (0.0) | 1.7 (1.7) | 0.3 | 2.1 (1.8) | 0.5 | 17.7 (9.7) | 32.3*§† |
| Content | 43.5 (10.5) | 52.9 (9.0) | 1.6 | 64.8 (10.0) | 8.3* | 49.4 (7.9) | 0.6 |
| Energetic | 26.0 (8.9) | 51.6 (8.5) | 17.0* | 53.3 (8.9) | 19.3* | 24.9 (7.6) | 18.5§† |
| Good drug effect | 2.3 (2.3) | 31.7 (10.3) | 38.1* | 55.8 (10.9) | 125.9* | 49.6 (11.6) | 98.5*§ |
| Heart pounding | 2.9 (2.9) | 16.8 (8.7) | 13.2* | 22.4 (10.4) | 25.8* | 20.9 (9.9) | 22.1* |
| High | 3.0 (2.7) | 37.4 (10.1) | 72.2* | 51.9 (8.5) | 146.2*§ | 62.1 (10.8) | 213.5*§† |
| Social | 38.6 (8.7) | 57.2 (6.8) | 12.8* | 53.5 (7.8) | 8.3* | 41.2 (9.9) | 9.5§† |
| Stimulated | 8.2 (4.1) | 40.5 (8.6) | 62.5* | 54.4 (6.1) | 127.4*§ | 45.5 (11.1) | 83.4* |
| Sweating | 0.0 (0.0) | 8.6 (5.0) | 5.0 | 19.8 (9.0) | 26.6*§ | 32.3 (12.4) | 70.4*§ † |
| Talkative | 31.7 (10.5) | 34.2 (10.8) | 0.1 | 49.5 (8.5) | 7.6*§ | 27.5 (8.6) | 11.6† |
| Want cigarette | 10.7 (5.2) | 25.2 (11.0) | 3.8 | 19.4 (7.9) | 1.3 | 31.2 (10.9) | 7.6* |
| Peak “negative” subjective-effect ratings | |||||||
| Bad drug effect | 1.1 (1.1) | 6.6 (4.8) | 3.1 | 0.4 (0.4) | 0.1 | 20.9 (8.4) | 39.1*§† |
| Can't concentrate | 10.7 (8.0) | 6.4 (6.0) | 0.5 | 13.6 (6.7) | 0.2 | 34.6 (10.4) | 14.9*§† |
| Clumsy | 2.1 (1.8) | 5.3 (4.7) | 0.8 | 6.2 (5.8) | 1.2 | 21.3 (9.6) | 27.1*§† |
| Confused | 5.5 (3.2) | 6.4 (6.1) | 0.0 | 9.5 (6.4) | 1.2 | 21.3 (8.9) | 18.3*§† |
| Dizzy | 2.9 (2.9) | 4.8 (4.0) | 0.3 | 5.9 (5.2) | 0.8 | 26.4 (11.1) | 49.7*§† |
| Jittery | 1.6 (2.6) | 13.8 (7.6) | 13.9* | 8.0 (3.8) | 3.8 | 34.2 (10.0) | 99.2*§† |
| Nauseous | 2.5 (2.1) | 1.5 (1.5) | 0.1 | 0.0 (0.0) | 0.7 | 15.1 (8.2) | 17.0*§† |
| Restless | 11.6 (7.2) | 17.5 (9.2) | 1.4 | 9.6 (6.9) | 0.2 | 24.5 (10.9) | 6.6*† |
| Sedated | 0.9 (0.9) | 2.8 (2.5) | 0.2 | 5.8 (5.8) | 1.4 | 26.9 (10.5) | 38.9*§† |
*
p<0.05, significantly different from placebo
§
p<0.05, significantly different from 20 mg MA
†
p<0.05, significantly different from 40 mg MA