. Author manuscript; available in PMC: 2015 May 14.

Published in final edited form as: Psychopharmacology (Berl). 2011 Jun 30;219(1):109–122. doi: 10.1007/s00213-011-2383-4

Table 3. Amphetamine-related effects on sleep measures and food intake (day and night 1).

	Drug conditions

	Placebo	20 mg MA		40 mg MA		100 mg MDMA

	Mean (SEM)	Mean (SEM)	F value	Mean (SEM)	F value	Mean (SEM)	F value
Sleep questionnaire (measurements from night 1)
Slept well	63.6 (5.9)	36.9 (10.3)	11.2^*	41.4 (10.1)	7.8^*	73.9 (6.3)	21.5^§^†
Woke often	32.5 (8.5)	47.7 (10.2)	3.4	53.8 (9.8)	6.7^*	18.2 (7.8)	13.0^§^†
Satisfied with sleep	57.9 (6.8)	33.4 (8.9)	9.4^*	34.5 (9.3)	8.6^*	65.5 (9.0)	16.1^§^†
Woke early	41.3 (9.3)	44.1 (11.3)	0.1	63.5 (13.5)	4.1	19.4 (6.3)	5.1^§^†
Actiwatch measures (measurements from night 1)
Sleep efficiency (%)	84.9 (1.8)	67.4 (7.1)	32.9^*	71.6 (2.9)	19.2^*	90.3 (1.2)	56.7^§^†
# of awakenings per hour	2.9 (0.3)	2.6 (0.3)	0.8	3.8 (0.4)	9.0^*^§	2.7 (0.3)	6.2^†
Awakenings duration (min)	1.7 (0.2)	1.7 (0.1)	0.0	2.1 (0.2)	8.7^*^§	1.4 (0.1)	23.4^†
Food intake (measurements from day 1)
Total # of eating occasions	10.1 (1.0)	5.7 (0.7)	34.6^*	5.5 (0.6)	37.5^*	7.5 (0.9)	12.6^*^§^†
Protein
Total consumed (g)	94.5 (6.5)	41.8 (7.4)	73.4^*	40.2 (8.1)	77.8^*	56.6 (5.5)	37.9^*^§^†
Prop. of total calories (%)	12.5 (0.9)	11.4 (2.1)	1.7	11.1 (1.5)	2.9	10.8 (1.2)	4.3
Carbohydrates
Total consumed (g)	448.4 (53.6)	262.6 (36.1)	38.8^*	244.3 (37.6)	44.4^*	341.3 (45.8)	12.2^*^§^†
Prop. of total calories (%)	54.9 (2.0)	65.9 (4.7)	14.9^*	66.1 (4.0)	15.4^*	59.1 (2.6)	5.9^§^†
Fat
Total consumed (g)	121.0 (17.7)	36.3 (5.3)	47.4^*	45.1 (15.0)	38.1^*	76.9 (10.4)	12.9^*^§^†
Prop. of total calories (%)	32.6 (2.5)	22.7 (3.3)	14.7^*	22.9 (3.1)	14.2^*	30.1 (3.0)	8.3^§^†

p<0.05, significantly different from placebo

^§

p<0.05, significantly different from 20 mg MA

^†

p<0.05, significantly different from 40 mg MA