Table 3.
Association of Demographic, and Laboratory Characteristics with eGFRcys <60 ml/min/1.73m2
| Mean (SD)* |
eGFRcys ≥60 (N=212) |
eGFRcys <60 (N=38) |
P-value |
|---|---|---|---|
| Creatinine (mg/dl) | 0.74 (0.19) | 0.90 (0.32) | 0.003 |
| Cystatin C (mg/L) | 0.94 (0.14) | 1.50 (0.27) | <0.0001 |
| eGFRcreat (ml/min/1.73m2) | 123 (40) | 105 (64) | <0.0001 |
| eGFRcys (ml/min/1.73m2) | 85 (15) | 49 (8) | <0.0001 |
| Age (years) | 41.4 (5.2) | 44.1 (4.7) | 0.05 |
| HCVAntibody (%) | 33.9 | 63.2 | 0.0007 |
| ALT (IU/L) Mean (SD) | 40 (31) | 62 (61) | 0.003 |
| Active Viral Hepatitis† | 33.3 | 73.7 | <0.0001 |
| Albumin | 3.99 (0.40) | 3.67 (0.41) | <0.0001 |
| CD4 cell count (cells/mm3) | 466 (271) | 311 (235) | 0.006 |
| Log viral load (copies/ml) | 2.74 (0.80) | 3.30 (1.33) | 0.009 |
| % undetectable log viral load | 70.3 | 52.6 | 0.03 |
| IDU ever (%) | 26.4 | 60.5 | <0.0001 |
| Fat Free Mass (kg) | 58.3 (10.8) | 53.3 (9.5) | 0.01 |
| Hemoglobin | 14.1 (1.7) | 13.5 (1.8) | 0.04 |
Abbreviations used in this table: standard deviation (SD), estimated glomerular filtration rate based on the Modification of Diet in Renal Disease estimating equation (eGFRcreat), estimated GFR based on the U01 study cystatin estimating equation (eGFRcys), hepatitis C virus (HCV), hepatitis B surface antigen (HBSAg), alanine aminotransferase (ALT), injection drug use (IDU).
To convert to SI units: for creatinine mg/dl to µmol/L, multiply value by 88.4; for albumin g/dL to g/L multiply value by 10; for hemoglobin g/dL to g/L, multiply value by 10.
None of the following covariates were significantly associated with eGFRcys < 60 ml/min/1.73m2: Race, sex, BMI, fat-free mass percent, years of known HIV infection, systolic or diastolic blood pressure , % taking tenofovir, % taking indinavir, or CRP.
Values represent mean and standard deviation (SD) unless otherwise indicated. P-values are from Wilcoxon models.
Participants with active viral hepatitis had either detectable hepatitis C virus (HCV) RNA or hepatitis B virus surface antigen (HBSAg). Hepatitis testing was available for 233 participants.