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Poxvirus membrane formation. Numerous viral transmembrane miniproteins are required for proper poxvirus membrane biogenesis, infectivity, and/or virulence. This transmission electron micrograph shows incomplete viral membranes (pseudocolored red) forming from endoplasmic reticulum (ER) membranes (purple) in cells infected with vaccinia virus lacking the A30.5 miniprotein. Adapted from Reference 71 with permission from the American Society for Microbiology.
