Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 16;13:25. doi: 10.1186/s12915-015-0132-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Herter et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Myc binds to vertebrate non-coding snoRNA host genes (SNHGs). A) ChIPseq traces of SNHG7 (left) and NCL (right; a well characterized, strongly Myc-bound gene) in human U2OS cells, both shown at the same vertical scale. B) ChIPseq traces of SNHG7 in murine T cells; the expression level of SNHG7 drops by 4.4-fold after silencing of transgenic Myc expression. C) ChIPseq traces for all 15 SNHG loci in U2OS cells. Each window is 2 kb wide. Horizontal bars below the input samples denote canonical E-boxes. Samples ‘ectopic Myc’ contain overexpressed Myc, samples ‘-‘ only endogenous Myc; overexpression of Myc was induced (A; tet-on system) or repressed (B; tet-off system) by the addition of doxycyclin. ChIPseq, chromatin immunoprecipitation sequencing; snoRNA, small nucleolar RNA.