Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 May 14;16(1):380. doi: 10.1186/s12864-015-1591-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Saritas-Yildirim et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

In X. tropicalis, human, and mouse, the consensus NRSE motifs share sequence similarity and the majority of the NRSE sites are farther than 20 kb from a gene, with a single copy per gene. A. Sequence logos of the consensus NRSE motif derived from 32 bona fide mouse REST target genes ([26], top panel), from 1301 human NRSE motifs ([25], middle panel), and from 742 X. tropicalis NRSE motifs (bottom panel). Arrowheads mark the differences between the Xenopus and human consensus motifs. B. In all three vertebrate genomes, ~ 65% of the motifs are located farther than 20 kb from a gene. C. 80% to 90% of the putative REST target genes in three organisms have a single NRSE motif within 100 kb of a gene.