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. 2015 May 14;16(1):380. doi: 10.1186/s12864-015-1591-4

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© Saritas-Yildirim et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Human NRSEs are associated with lncRNAs genome-wide but not in gene-distant regions. A. 17-24% of NRSE motifs in the human, mouse and frog genomes are located in gene-distant regions (GD). B. In the human genome, NRSEs within 100 kb of ncRNAs are associated with lncRNAs (chi-square, p = 0.00102547). In the figure, <100 kb denotes the NRSEs that are within 100 kb of a protein-coding gene and >100 kb is for NRSEs that are located in GD.