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. 2015 May 14;16(1):380. doi: 10.1186/s12864-015-1591-4

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© Saritas-Yildirim et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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REST mediated repression of coding and non-coding gene expression. In neural progenitors and non-neuronal cells, REST facilitates silencing of expression by binding to highly conserved NRSE elements and recruiting co-repressors and chromatin remodeling agent to convert the topology of the local DNA to heterochromatin. During neurogenesis, REST transcription is down regulated and the protein is degraded. The absence of REST in neuronal cells allows the expression of neuron specific protein-coding genes and non-coding RNAs including micro and long non-coding RNAs.