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. 2015 Apr 29;7(1):51. doi: 10.1186/s13148-015-0087-z

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© Gustafson et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The relative transcription levels of TETs and SVCTs in melanoma cells. Levels of TETs and SVCTs (mean) in a healthy melanocyte line are set up as ‘1’. (A) The mRNA levels of TET1 and TET2, measured by qRT-PCR, are decreased in melanoma cell lines derived from RGP, VGP, and metastatic stages compared to a healthy melanocyte line FOM-113. (B) The mRNA levels of SVCTs are either decreased or increased in the examined melanoma cell lines. Comparatively, the transcription levels of both SVCTs are decreased in the melanoma cell lines (C8161, A2058) derived from the metastatic stage. (Mean ± SD, *P < 0.05).