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. 2015 May 15;8:29. doi: 10.1186/s13041-015-0120-3

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© Imoto et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of X-ray irradiation on fluoxetine-induced adult neurogenesis and dematuration in the DG. (A) Experimental scheme. Mice were irradiated with X-rays (10 Gy) 14 days before initiation of fluoxetine treatment (ip, intraperitoneally injected). Mice were sacrificed 24 h after the final drug treatment. (B and C) Representative images of DCX (B) and calbindin (C) immunohistochemistry. Scale bars: 100 μm. (D) Quantification of calbindin-IR signal intensity in the GCL and the ML in control (Sham) and X-ray-irradiated mice. Data are expressed as the mean ± SEM (n =5 or 6). Main effect of drug: P < 0.0001 (GCL), P < 0.0001 (ML); main effect of X-ray irradiation: P = 0.0303 (GCL), P = 0.0087 (ML); interaction of drug and X-ray irradiation: P = 0.1089 (GCL), P = 0.2085 (ML); P values determined by two-way ANOVA.