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. 2015 Mar 21;15:24. doi: 10.1186/s12874-015-0009-y

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© Rota et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Applicative example on acute lymphoblastic leukemia. Panel A. Estimated survival curve with 95% confidence bands. Panel B. Histogram for the CRLF2 expression. Panel C. ROC curve for the CRLF2 biomarker with the three objective functions: the Youden index J(ĉ_J) represented by the thick line segment, the concordance probability CZ(ĉ_CZ) represented by the area of the dotted rectangle and the distance from the (0,1) corner represented by the thin line segment. The 95% elliptic asymptotic confidence interval of (FPF(ĉ), TPF(ĉ)) is also represented.