Table 4.
Youden index | Concordance probability | Point closest-to-(0,1) corner | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
J(c opt)‡ | CZ(c opt ) ‡ | c opt | N | Disease fraction | Relative bias | MSE | Relative bias | MSE | Relative bias | MSE |
0.2 | 0.36 | 0.25 | 100 | 15% | 0.2296 | 0.3298 | 0.4150 | 0.1390 | 0.4114 | 0.1060 |
150 | 33% | 0.2188 | 0.2089 | 0.1921 | 0.0611 | 0.1749 | 0.0440 | |||
200 | 25% | 0.0973 | 0.2125 | 0.1758 | 0.0666 | 0.1822 | 0.0482 | |||
250 | 20% | 0.1872 | 0.1871 | 0.2246 | 0.0592 | 0.2164 | 0.0421 | |||
0.4 | 0.49 | 0.52 | 100 | 15% | 0.1389 | 0.1944 | 0.2084 | 0.1320 | 0.2450 | 0.1051 |
150 | 33% | 0.0786 | 0.1048 | 0.0625 | 0.0575 | 0.0741 | 0.0370 | |||
200 | 25% | 0.0516 | 0.1147 | 0.0701 | 0.0606 | 0.0674 | 0.0381 | |||
250 | 20% | 0.0926 | 0.0990 | 0.0951 | 0.0528 | 0.0940 | 0.0346 | |||
0.6 | 0.64 | 0.84 | 100 | 15% | 0.1457 | 0.1658 | 0.1503 | 0.1366 | 0.1765 | 0.1101 |
150 | 33% | 0.0522 | 0.0778 | 0.0547 | 0.0590 | 0.0453 | 0.0367 | |||
200 | 25% | 0.0500 | 0.0744 | 0.0516 | 0.0512 | 0.0515 | 0.0286 | |||
250 | 20% | 0.0543 | 0.0742 | 0.0585 | 0.0569 | 0.0596 | 0.0344 | |||
0.8 | 0.81 | 1.28 | 100 | 15% | 0.1219 | 0.1534 | 0.1283 | 0.1478 | 0.1337 | 0.1274 |
150 | 33% | 0.0401 | 0.0702 | 0.0439 | 0.0645 | 0.0387 | 0.0432 | |||
200 | 25% | 0.0360 | 0.0568 | 0.0375 | 0.0513 | 0.0438 | 0.0364 | |||
250 | 20% | 0.0535 | 0.0641 | 0.0558 | 0.0585 | 0.0535 | 0.0390 |
†XZ ≤ τ ~ N(μZ ≤ τ, 1), XZ >τ ~ N(0, 1). ‡The levels of J and CZ are achieved by μZ ≤ τ = 0.51, 1.05, 1.68, 2.56, respectively.