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Manhattan plot of genome-wide association with perioperative myocardial infarction in stage I analysis. The x axis represents the genome in physical order (coloured by chromosome); the y axis showing –log10(p) for all single nucleotide polymorphisms (SNPs). None of the SNPs reached genome-wide significance (p<9.09×10−8), but 521 SNPs met the prespecified discovery threshold p<0.001 for inclusion in stage II analyses (minimum p=2.76×10−6, rs2044061 on chromosome 8).
