Table 1.

Top eight SNP associated with postoperative myocardial infarction

				Stage I: discovery data set*				Stage II: expanded data set*
				MAF				MAF
Chr	SNP	Base pair	Gene symbol	Controls N=1321	Cases N=112	OR (95% CI)	p Value	Controls N=1830	Cases N=225	OR (95% CI)	p Value
1	rs10489478	176 566 350	PAPPA2	0.18	0.09	0.41 (0.25 to 0.66)	2.67×10−4	0.18	0.11	0.47 (0.34 to 0.65)	4.70×10−6
1	rs10913237	176 630 416	PAPPA2	0.18	0.09	0.39 (0.24 to 0.64)	1.85×10−4	0.19	0.11	0.46 (0.33 to 0.63)	2.47×10−6
1	rs10454444	176 649 181	PAPPA2	0.18	0.09	0.39 (0.24 to 0.64)1	1.81×10−4	0.19	0.11	0.46 (0.33 to 0.63)	2.43×10−6
2	rs10 200 850	240 234 901	HDAC4	0.06	0.13	2.22 (1.42 to 3.46)	4.34×10−4	0.06	0.11	2.23 (1.57 to 3.17)	8.18×10−6
4	rs4834703	119 691 624	SEC24D	0.09	0.18	2.27 (1.54 to 3.34)	3.13×10−5	0.09	0.16	1.98 (1.47 to 2.66)	6.80×10−6
4	rs6822035	119 710 421	SEC24D	0.29	0.40	1.73 (1.29 to 2.33)	2.59×10−4	0.28	0.36	1.65 (1.32 to 2.05)	9.55×10−6
12	rs2303970	74 471 340	TRHDE|LOC552889	0.48	0.35	0.58 (0.43 to 0.78)	3.51×10−4	0.48	0.36	0.62 (0.50 to 0.76)	8.89×10−6
13	rs609418	37 417 427	RFXAP | SMAD9	0.25	0.35	1.73 (1.28 to 2.33)	3.14×10−4	0.25	0.33	1.67 (1.34 to 2.09)	5.81×10−6

*Adjusted for clinical characteristics including extracardiac arteriopathy, recent myocardial infarction, procedure other than CABG only, year of surgery, number of diseased vessels and aortic cross-clamp time.

HDAC4, histone deacetylase-4; PAPPA2, pregnancy-associated plasma protein A2; RFXAP, regulatory factor X-associated protein; SEC24D, SEC24-related protein D; SMAD9, mother against decapentaplegic homolog 9; TRHDE, thyrotropin-releasing hormone-degrading ectoenzyme; intergenic region is expressed by two franking genes with ‘|’ in between.

CABG, coronary artery bypass grafting; Chr, chromosome; MAF, minor allele frequency (based on the discovery data set); SNP, single nucleotide polymorphisms.