Table 2.
Association of the top eight SNP with CK-MB as a quantitative trait and as an extreme phenotype in the joint analysis data set
| MAF (Overall) | CK-MB as a quantitative trait* |
CK-MB as an extreme phenotype* |
||||||
|---|---|---|---|---|---|---|---|---|
| Chr | SNP | Base pair | Gene symbol | β-Coefficient | p Value | OR (95% CI) | p Value | |
| 1 | rs10489478 | 176 566 350 | PAPPA2 | 0.17 | −5.40 | 2.27×10−4 | 0.77 (0.574 to 1.047) | 0.1 |
| 1 | rs10913237 | 176 630 416 | PAPPA2 | 0.18 | −5.58 | 1.30×10−4 | 0.78 (0.578 to 1.052) | 0.1 |
| 1 | rs10454444 | 176 649 181 | PAPPA2 | 0.18 | −5.59 | 1.21×10−4 | 0.77 (0.575 to 1.043) | 0.09 |
| 2 | rs10200850 | 240 234 901 | HDAC4 | 0.07 | 9.26 | 8.26×10−5 | 1.49 (0.950 to 2.326) | 0.08 |
| 4 | rs4834703 | 119 691 624 | SEC24D | 0.10 | 8.54 | 7.72×10−6 | 1.82 (1.242 to 2.654) | 0.002 |
| 4 | rs6822035 | 119 710 421 | SEC24D | 0.30 | 4.42 | 4.81×10−4 | 1.48 (1.152 to 1.903) | 0.002 |
| 12 | rs2303970 | 74 471 340 | TRHDE|LOC552889 | 0.47 | −2.93 | 0.01 | 0.84 (0.669 to 1.047) | 0.12 |
| 13 | rs609418 | 37 417 427 | RFXAP|SMAD9 | 0.26 | 4.80 | 2.26×10−4 | 1.56 (1.189 to 2.034) | 0.001 |
*Adjusted for clinical characteristics including extracardiac arteriopathy, recent myocardial infarction, procedure other than CABG only, year of surgery, number of diseased vessels, and aortic cross-clamp time using either linear regression (Β-coefficient) or logistic regression (OR, 95% CI) analyses.
HDAC4, histone deacetylase-4; PAPPA2, pregnancy-associated plasma protein A2; RFXAP, regulatory factor X-associated protein; SEC24D, SEC24-related protein D; SMAD9, mother against decapentaplegic homolog 9; TRHDE, thyrotropin-releasing hormone-degrading ectoenzyme.
CABG, coronary artery bypass grafting; Chr, chromosome; CK-MB, creatine kinase MB isoenzyme; MAF, minor allele frequency (based on the expanded data set); SNP, single nucleotide polymorphisms.