Table 3.
Estimated haplotype frequencies in the SEC24D gene and results of association tests with incidence of PMI in the stage II analysis cohort (n=2055)
| Haplotype frequency |
||||||
|---|---|---|---|---|---|---|
| SNP1 | SNP2 | Haplotype | Patients with PMI (n=225) | Patients without PMI (n=1830) | OR (95% CI) | p Value |
| rs6828577 | rs6822035 | A-A | 0.3956 | 0.2874 | 1.65 (1.33 to 2.06) | 8.84×10−6 |
| rs6828577 | rs6822035 | G-C | 0.6044 | 0.7126 | Reference | |
| rs6822035 | rs10518325 | A-G | 0.03516 | 0.0528 | 0.86 (0.43 to 1.70) | 0.657 |
| rs6822035 | rs10518325 | C-G | 0.009083 | 0.02636 | 1.39 (0.67 to 2.90) | 0.378 |
| rs6822035 | rs10518325 | A-A | 0.3631 | 0.2358 | 1.87 (1.46 to 2.39) | 5.54×10−7 |
| rs6822035 | rs10518325 | C-A | 0.5927 | 0.685 | Reference | |
| rs10518325 | rs11098451 | A-A | 0.03097 | 0.06231 | 0.76 (0.48 to 1.19) | 0.225 |
| rs10518325 | rs11098451 | G-G | 0.04425 | 0.07845 | 0.87 (0.58 to 1.31) | 0.509 |
| rs10518325 | rs11098451 | A-G | 0.9248 | 0.8592 | Reference | |
Adjusted for clinical characteristics including extracardiac arteriopathy, recent myocardial infarction, procedure other than CABG only, year of surgery, number of diseased vessels, aortic cross-clamp time.
CABG, coronary artery bypass grafting; PMI, perioperative myocardial infarction; SNP, single nucleotide polymorphism.