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. 2015 Apr 15;15(4):8787–8831. doi: 10.3390/s150408787

Table 10.

Differences between SPR and LSPR sensors [96,110,199].

Different Parameter SPR LSPR
Refractive index sensitivity ~2 × 106 nm/RIU ~2 × 102 nm/RIU
Overall sensitivity The sensitivity of LSPR sensors are better than that of the traditional SPR sensors without metallic nanostructures
Decay length ~200 nm ~6 nm
Throughput LSPR technology has high-throughput screening capabilities in a highly compact design
Controls over angle of incidence Needs precise control No precise control is needed
Controls over ambient temperature Needs precise control No precise control is needed
Nature of Measurement Invasive Non-invasive
Use in in vivo quantification LSPR is better for in vivo quantification than SPR