Table 2. Effects on biomarkers of antioxidant in hippocampus.
| Treatment | Naive | Control | PNE (mg/kg) | Tacrine (mg/kg) | ||
|---|---|---|---|---|---|---|
| 25 | 50 | 100 | 10 | |||
| TAC (μM/mg protein) | 59.86 ± 10.34 | 40.82 ± 5.87### | 56.88 ± 3.81*** | 58.17 ± 5.81*** | 57.58 ± 6.68*** | 55.96 ± 3.95*** |
| GSH (μM/mg protein) | 11.20 ± 0.97 | 7.24 ± 1.69### | 9.69 ± 0.69*** | 10.47 ± 1.17*** | 9.80 ± 0.71*** | 8.20 ± 0.84 |
| GSH-Rd (U/mg protein) | 4.62 ± 0.33 | 3.47 ± 0.48### | 3.78 ± 0.68 | 4.16 ± 0.29** | 4.07 ± 0.51* | 3.58 ± 0.25 |
| GST (U/mg protein) | 0.37 ± 0.06 | 0.29 ± 0.03## | 0.30 ± 0.02 | 0.37 ± 0.08** | 0.38 ± 0.03*** | 0.30 ± 0.03 |
| SOD (U/mg protein) | 38.92 ± 7.11 | 32.30 ± 2.03# | 40.98 ± 5.80* | 39.59 ± 6.43* | 42.69 ± 7.72** | 33.55 ± 5.58 |
| Catalase (U/mg protein) | 737.43 ± 116.15 | 575.57 ± 32.14### | 642.21 ± 68.24 | 664.07 ± 60.39* | 685.07 ± 33.59** | 610.46 ±56.44 |
Data are expressed as the mean ± SD (n = 7). #P < 0.05, ##P < 0.01, ###P < 0.001 compared with the naïve group; *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group.
TAC, total antioxidant capacity; GSH, glutathione; GSH-Rd, glutathione reductase; GST. glutathione S-transferase; SOD, superoxide dismutase.