Table 2.
Weibull univariable and multivariable analysis for predictors of time to attrition (lost to follow up and death) among adults initiated antiretroviral care in a rural HIV clinic in Coastal Kenya (N = 928)
| Univariable Regression | Multivariable regression (n = 761) | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Categories | Attrition, n = 308 (n/100 pyo [rate]) | Crude HR | 95% CI | LRT p-value | Adjusted HR | 95% CI | LRT p-value |
| Gender | Female | 208/9.92 [21.0] | 1.0 | (Reference) | 1.0 | (Reference) | ||
| Male | 100/3.44 [29.1] | 1.3 | 1.1 – 1.7 | 0.018 | 1.5 | 1.1 – 2.0 | 0.014 | |
| Age group (years) | 15 – 24 | 38/1.24 [30.6] | 1.5 | 1.0 – 2.2 | 2.2 | 1.3 – 3.7 | ||
| 25 – 34 | 103/4.59 [22.4] | 1.1 | 0.8 – 1.6 | 1.4 | 0.9 – 2.1 | |||
| 35 – 44 | 112/4.74 [23.6] | 1.2 | 0.9 – 1.6 | 1.3 | 0.9 – 2.0 | |||
| ≥45 | 55/2.78 [19.8] | 1.0 | (Reference) | 0.318 | 1.0 | (Reference) | 0.034 | |
| *Marital status | Single | 28/0.97 [29.0] | 1.0 | (Reference) | ||||
| Married, Monogamous | 128/5.69 [22.5] | 0.8 | 0.5 – 1.2 | |||||
| Married, Polygamous | 48/2.39 [20.1] | 0.7 | 0.4 – 1.1 | |||||
| Separated/Divorced/Widowed | 103/4.29 [24.0] | 0.8 | 0.5 – 1.3 | 0.548 | ||||
| *Religion | Christian | 188/8.02 [23.4] | 1.0 | (Reference) | ||||
| Muslim | 55/2.37 [23.3] | 1.0 | 0.7 – 1.4 | |||||
| Others | 60/2.83 [21.2] | 0.9 | 0.7 – 1.2 | 0.859 | ||||
| *Education | No formal education | 104/4.59 [22.6] | 1.0 | (Reference) | ||||
| Primary education | 144/6.02 [23.9] | 1.0 | 0.8 – 1.3 | |||||
| Secondary/Higher education | 54/2.61 [20.7] | 0.9 | 0.6 – 1.2 | 0.608 | ||||
| *Distance from hospital (km) | 0 – 5 | 119/5.0 [23.7] | 1.0 | (Reference) | ||||
| 5 – 10 | 57/3.2 [18.1] | 0.8 | 0.6 – 1.1 | |||||
| ≥10 | 82/3.9 [21.2] | 0.9 | 0.7 – 1.2 | 0.270 | ||||
| Pre-ART duration (months) | <12 | 207/8.6 [24.0] | 1.0 | (Reference) | ||||
| 12 – 36 | 68/3.2 [20.9] | 0.9 | 0.7 – 1.2 | |||||
| ≥36 | 33/1.5 [22.1] | 0.9 | 0.6 – 1.4 | 0.663 | ||||
| *Baseline WHO clinical staging | Stage I/II | 141/8.13 [17.4] | 1.0 | (Reference) | 1.0 | |||
| Stage III/IV | 124/5.05 [24.5] | 1.4 | 1.1 – 1.8 | 0.009 | 1.1 | 0.8 – 1.5 | 0.527 | |
| *Baseline BMI (Kg/m2) | <16.0 | 41/1.12 [36.7] | 2.1 | 1.5 – 2.9 | 1.6 | 1.0 – 2.4 | ||
| 16.0 – 18.5 | 72/3.53 [20.4] | 1.2 | 0.9 – 1.6 | 1.0 | 0.7 – 1.4 | |||
| ≥18.5 | 128/7.58 [16.9] | 1.0 | (Reference) | <0.001 | 1.0 | (Reference) | 0.110 | |
| Baseline CD4 (cells/uL) | 0 – 100 | 70/2.50 [28.0] | 1.0 | (Reference) | 1.0 | (Reference) | ||
| 100 – 350 | 54/4.46 [12.1] | 0.5 | 0.3 – 0.7 | 0.5 | 0.3 – 0.7 | |||
| ≥350 | 15/0.66 [22.6] | 0.8 | 0.5 – 1.4 | 0.8 | 0.4 – 1.5 | |||
| Missing | 169/5.74 [29.4] | 1.1 | 0.8 – 1.4 | <0.001 | 0.7 | 0.5 – 1.0 | 0.002 | |
ART (Antiretroviral therapy), BMI (Body Mass Index), LRT (Likelihood Ratio Test), pyo (person years of observation), WHO (World Health Organization).
*Participants excluded from Weibull regression analysis (n = 167) due to missing marital status (n = 2), religion (n = 10), education status (n = 9), distance from hospital (n = 115), baseline WHO clinical staging (n = 59) and/or BMI (n = 123) data.