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| HPV protein | Functions | Cellular targets |
|---|---|---|
| E7 | major oncoprotein, cell cycle arrest | pRb, p107, p130 |
| E6 | major oncoprotein, cell proliferation, block apoptosis | p53, E6AP, CBP, p300, Bak, hTERT, MAGUK, cIAP, survivin |
| E5 | mediates mitogenic signal of growth factors/early stage transformation stage | — |
| E4 | destabilization of cytokeratin network | — |
| E2 | viral DNA replication and transcription | — |
| E1 | viral DNA replication | — |
