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IL-8 promotes LYVE-1 protein expression in LECs (immunofluorescence staining, ×630). Cell nuclei counterstained with DAPI (blue) and LYVE-1 stained with Cy3 (red). LYVE-1 protein was found on the cell membrane and in the cytoplasm. IL-8, interleukin-8; LYVE-1, lymphatic vessel endothelial hyaluronic acid receptor-1; LECs, lymphatic endothelial cells. (A) 0, (B) 0.2, (C) 0.5, (D) 0.8 and (E) 1.0 ng/ml group.
