Table 2.
Variable | n | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P -value | Hazard ratio | 95% CI | P -value | ||
Age (≥65) | 97 | 1.38 | 0.73 – 2.70 | 0.327 | |||
Gender (male) | 128 | 1.27 | 0.60 – 2.49 | 0.517 | |||
Tumor location (distal) | 107 | 0.42 | 0.22 – 0.78 | 0.006 | 0.53 | 0.27 – 1.05 | 0.067 |
Carcinoembryonic antigen (>5 ng/ml) | 27 | 1.71 | 0.73 – 3.56 | 0.202 | |||
Carbohydrate antigen 19–9 (>37 IU/ml) | 23 | 2.33 | 0.99 – 4.90 | 0.054 | |||
Tumor size (≥50 mm) | 76 | 3.02 | 1.54 – 6.35 | 0.001 | 2.06 | 0.98 – 4.57 | 0.056 |
Tumor depth (pT4, UICC) | 55 | 2.82 | 1.50 – 5.39 | 0.001 | 1.09 | 0.52 – 2.32 | 0.815 |
Tumor differentiation (undifferentiated) | 89 | 1.79 | 0.93 – 3.60 | 0.081 | |||
Lymphatic involvement | 137 | 5.70 | 1.74 – 35.2 | 0.002 | 1.12 | 0.14 – 6.12 | 0.905 |
Vessel invasion | 83 | 4.10 | 2.02 – 9.20 | <0.001 | 2.93 | 1.31 – 7.52 | 0.008* |
Invasive growth | 41 | 2.51 | 1.31 – 4.73 | 0.006 | 1.39 | 0.64 – 3.00 | 0.404 |
Lymph node metastasis | 86 | 8.70 | 3.71 – 25.5 | <0.001 | 4.01 | 1.40 – 14.6 | 0.008* |
Expression of DPYSL-3 mRNA (high) | 84 | 2.36 | 1.22 – 4.72 | 0.010 | 2.22 | 1.14 – 4.49 | 0.019* |
*Statistically significant in multivariable analysis. GC, gastric cancer; CI, confidence interval; UICC, Union for International Cancer Control.