Table 2.

Prognostic factors for disease specific survival in 169 patients who underwent curative surgery

Variable	n	Univariate			Multivariate
		Hazard ratio	95% CI	P -value	Hazard ratio	95% CI	P -value
Age (≥65)	97	1.38	0.73 – 2.70	0.327
Gender (male)	128	1.27	0.60 – 2.49	0.517
Tumor location (distal)	107	0.42	0.22 – 0.78	0.006	0.53	0.27 – 1.05	0.067
Carcinoembryonic antigen (>5 ng/ml)	27	1.71	0.73 – 3.56	0.202
Carbohydrate antigen 19–9 (>37 IU/ml)	23	2.33	0.99 – 4.90	0.054
Tumor size (≥50 mm)	76	3.02	1.54 – 6.35	0.001	2.06	0.98 – 4.57	0.056
Tumor depth (pT4, UICC)	55	2.82	1.50 – 5.39	0.001	1.09	0.52 – 2.32	0.815
Tumor differentiation (undifferentiated)	89	1.79	0.93 – 3.60	0.081
Lymphatic involvement	137	5.70	1.74 – 35.2	0.002	1.12	0.14 – 6.12	0.905
Vessel invasion	83	4.10	2.02 – 9.20	<0.001	2.93	1.31 – 7.52	0.008*
Invasive growth	41	2.51	1.31 – 4.73	0.006	1.39	0.64 – 3.00	0.404
Lymph node metastasis	86	8.70	3.71 – 25.5	<0.001	4.01	1.40 – 14.6	0.008*
Expression of DPYSL-3 mRNA (high)	84	2.36	1.22 – 4.72	0.010	2.22	1.14 – 4.49	0.019*

*Statistically significant in multivariable analysis. GC, gastric cancer; CI, confidence interval; UICC, Union for International Cancer Control.