TABLE 1. Age-Related Changes of the Averaged Computed Tomographic Perfusion and Bone Mineral Density Values of Both the Third and Fourth Lumbar Vertebral Marrow.

Parameters	Age Groups									Statistical Analysis
	10 yr (I)	16 yr (II)	26 yr (III)	36 yr (IV)	46 yr (V)	56 yr (VI)	66 yr (VII)	76 yr (VIII)	Univariate Tests	Pairwise Comparisons (Significance) *†
BMD	177.5 ± 32.1	207.6 ± 35.4	214.3 ± 50.4	212.9 ± 28.4	167.9 ± 39.4	137.2 ± 25.5	118.5 ± 42.2	102.5 ± 55.8	F = 28.7, P = 0.00	PV-,II,III,IV, = 0.02,0.00,0.00,0.00
										PVI-I,II,III,IV, = 0.00,0.00,0.00,0.00
										PVII-I,II,III,IV,V, = 0.00,0.00,0.00,0.00,0.00
										PVIII-I,II,III,IV,V, = 0.00,0.00,0.00,0.00,0.00
BF	48.0 ± 13.2	52.7 ± 25.7	52.3 ± 20.7	47.0 ± 16.2	40.3 ± 16.9	36.3 ± 11.4	34.0 ± 11.6	31.2 ± 16.0	F = 5.7, P = 0.00	PII -VI,VII,VIII = 0.03,0.01,0.00
										PIII-VI,VII,VIII = 0.04,0.01,0.00
BV	14.3 ± 7.5	14.9 ± 9.7	15.0 ± 9.8	12.8 ± 5.1	11.1 ± 7.5	9.0 ± 5.8	8.2 ± 3.6	7.1 ± 6.8	F = 4.4, P = 0.00	PII -VII,VIII = 0.05,0.01
										PIII-,VII,VIII = 0.04,0.01
TTP	16.7 ± 2.3	15.4 ± 2.0	15.6 ± 2.4	16.1 ± 2.9	16.7 ± 1.9	18.1 ± 3.8	18.0 ± 3.4	18.4 ± 2 .3	F = 4.7, P = 0.00	PII -VI,VII,VIII = 0.04,0.01,0.01
										PIII-VI,VII,VIII = 0.05,0.01,0.01
PMB	43.6 ± 13.1	54.5 ± 43.6	55.3 ± 33.7	49.0 ± 18.1	38.7 ± 10.6	35.1 ± 18.5	28.0 ± 10.7	26.7 ± 8.4	F = 5.6, P = 0.00	PII -VII,VIII = 0.00,0.00
										PIII-VII,VIII = 0.00,0.00
										PIV-VII,VIII = 0.05,0.03
MTT	11.0 ± 4.4	7.6 ± 4.2	8.0 ± 4.4	10.2 ± 3.3	13.2 ± 4.0	14.0 ± 4.9	15.8 ± 4.6	18.5 ± 5.2	F = 17.5, P = 0.00	PI -VII = 0.02, PII-V,VI,VII = 0.00,0.00,0.00
										PIII-V,VI,VII, = 0.00,0.00,0.00
										PIV-VII, = 0.00,
										PVIII-I,II,III,IV,V,VI, = 0.00,0.00,0.00,0.00,0.00,0.02
*The mean difference is signifi cant at the 0.05 level.
† Adjustment for multiple comparisons: Bonferroni.
BMD indicates bone mineral density; BF, blood flow; BV, blood volume; TTP, time to peak; PMB, permeability; MTT, mean transit time.