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. 2015 May 8;10:3429–3445. doi: 10.2147/IJN.S75936

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© 2015 Strehl et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Influence of a-PVA-SPION on the viability of isolated monocytes and monocyte-derived macrophages (MDMs).

Notes: Human monocytes (A) n=8 or MDMs (B) n=10 were incubated for 20 hours with or without SPION at varying concentrations and the percentage of Annexin V/7AAD negative cells was determined. In another experiment the SPION were added during the differentiation process from monocytes to MDMs at the beginning (0 d), after 24 hours (1 d) or after 72 hours (3 d) and the percentage of Annexin V/7AAD negative cells was determined after a total of 6 days (C) n=7. Results are normalized to cell counts and untreated control. Data are given as mean ± standard deviation; two-way ANOVA: ***P<0.001; **P<0.01; *P<0.05.

Abbreviations: d, day(s); ANOVA, analysis of variance; Ctrl, control; LPS, lipopolysaccharide; 7AAD, 7-amino-actinomycin D; a-PVA-SPION, amino-polyvinyl alcohol coated superparamagnetic iron oxide nanoparticles.