Figure 2. Reduced H₂O₂ production by mitochondria from Tg(PRDX3) mice.

A. Levels of H₂O₂ produced by mitochondria isolated from brain were measured as described by Muller et al (2007b).

B. Levels of H₂O₂ produced by mitochondria isolated from skeletal muscle were measured as described by Muller et al (2007b).

C. Levels of ATP production by mitochondria isolated from brain were measured as described in Methods.

D. Mitochondrial membrane potential of isolated mitochondria from brain was measured as described in Methods.

State 1: without substrate; Glut/Malate: with substrates of glutamate/malate; Suc+Rot: with substrate of succinate plus rotenone. *: P< 0.05. n=3–4.