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. Author manuscript; available in PMC: 2015 May 14.
Published in final edited form as: Cancer Lett. 2012 Feb 11;322(1):1–7. doi: 10.1016/j.canlet.2012.02.002

Figure 1. Proposed hierarchy of ovarian cancer stem cell differentiation based on the current literature.

Figure 1

A rare common ovarian CSC, for which markers have yet to be defined can give rise to either an ALDH+CD133+ early progenitor or a CD44+CD117+ early progenitor. Each of which can subsequently divide into more differentiated progenitors. The potential for expression of CD24 and CD44 in both lineages is indicated by the colored bars. Rounded arrows indicate cells with self-renewal capacity which have the potential to serve as CSC. Small arrows indicate the unproven potential for 'de-differentiation'.