Table 3.
Adverse events. Values are numbers (percentages) unless stated otherwise
| Adverse event | Trimethoprim-sulfamethoxazole | Vancomycin | Risk ratio (95% CI) |
|---|---|---|---|
| Any | 39/132 (30) | 26/115 (23) | 1.31 (0.85 to 2.01) |
| Requiring discontinuation | 14/132 (11) | 8/115 (7) | 1.52 (0.66 to 3.5) |
| RIFLE day 7*: | (n=108) | (n=100) | |
| None | 90 (83) | 86 (86) | Reference |
| Risk | 7 (6) | 2 (2) | 3.18 (0.68 to 14.88) |
| Injury | 11 (10) | 8 (8) | 1.28 (0.54 to 2.04) |
| Failure | 0 | 4 (4) | Not assessed |
| RIFLE risk, injury, or failure, day 7* | 18/108 (17) | 14/100 (14) | 1.19 (0.63 to 2.26) |
| RIFLE day 30*: | (n=87) | (n=86) | |
| None | 75 (86) | 68 (79) | Reference |
| Risk | 2 (2) | 4 (5) | 0.47 (0.09 to 2.48) |
| Injury | 3 (3) | 10 (12) | 0.3 (0.09 to 1.05) |
| Failure | 7 (8) | 4 (5) | 1.54 (0.47 to 5.04) |
| RIFLE risk, injury, or failure, day 30* | 12/87 (14) | 18/86 (21) | 0.66 (0.34 to 1.28) |
| Any rash | 12/132 (9) | 12/115 (104) | 0.87 (0.41 to 1.86) |
| Diarrhoea† | 12/132 (9) | 11/115 (10) | 0.95 (0.44 to 2.07) |