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(A) Anti-chromatin autoantibody titers measured during twice—weekly dosing with vehicle or 50 mg/kg ganetespib for 14 weeks. Inverse titers are shown. (B) Fold-changes in circulating anti-dsDNA levels were determined following the 14 week treatment period. (C) Percentage changes in total serum IgG levels assessed after the 14 week treatment period. Serum changes in age-matched non-lupus MRL/Mp mice are included as a control.
