Table 1. Linkage Peaks with PPL > 0.35 from All Analyses.
------Maximizing Model------ | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||
Phenotype | Chr | cM | PPL | Band range | Width (Mb) | LOD | -/- | +/- | +/+ | DGF | α |
YBOCS | 13 | 58 | 0.36 | q14.3-21.3 | 17.3 | 4.2 | -3.0 | 0.0 | 3.0 | 0.300 | 0.7 |
SRS-DT | 14 | 117 | 0.37 | q32.2-32.23 | 7.6 | 3.5 | 0.00 | 0.10 | 0.80 | 0.100 | 1.0 |
LI* | 15 | 83 | 0.57 | q23-26.2 | 24.2 | 4.1 | 0.00 | 0.70 | 0.99 | 0.001 | 1.0 |
SRS-QT | 15 | 120 | 0.52 | q26.2-26.3 | 6.2 | 4.5 | -2.0 | 1.0 | 2.0 | 0.100 | 0.9 |
RI* | 16 | 43 | 0.36 | p12.1-12.3 | 8.9 | 4.6 | 0.00 | 0.00 | 0.90 | 0.200 | 1.0 |
PPL is the posterior probability of linkage. LOD is the fully maximized LOD score, sometimes referred to as a MOD score. -/-, +/-, and +/+ are the estimated genotypic effects for the locus; for categorical analysis these quantities are penetrances and for quantitative traits they are genotypic means on a z-score scale. DGF is the disease gene frequency and α is the heterogeneity parameter in the admixture likelihood at the maximizing model.
Phenotypes are: YOBCS=Yale-Brown Obsessive Compulsive Scale, SRS-DT=Social Responsiveness Scale- Dichotomous trait, LI*=Oral Language Impairment and/or ASD, SRS-QT=Social Responsiveness Scale-Quantitative Trait, RI*= Written Language (Reading) Impairment and/or ASD.