Table 3.

Multivariate regression model of recurrence pattern: predictors of distant metastases (n=115)

	N (%)	Odds Ratio	P value
Adjuvant therapy	43 (39%)	1.2	0.8
SMAD4	37 (32%)	1.2	0.8
Positive lymph nodes	81 (70%)	6.0	0.001
Positive resection margin	16 (14%)	1.3	0.8
Poor differentiation	39 (34%)	1.1	0.9
Size > 3 cm	73(64%)	1.9	0.3

The results are consistent when adjuvant chemotherapy or radiation are substituted for adjuvant therapy. The regressions estimate the risk of distant metastases. Patients in the 'distant recurrence only' category are grouped with patients who had both 'local and distant recurrence.' Patients with no evidence of disease (n=12) were excluded from the regression model, as many will recur at some point in the future.