Table 1. Regional activation related to task conditions.

Location of cluster peak	side	MNI coordinates of peak	Extent	Peak voxel T-score
Hypoxia greater than normoxia
Ventral occipital and fusiform cortices bilaterally	L	-12,-84,-12	17285	5.20
	R	16,-78,-8		5.15
	R	20,-80,-18		5.09
Brainstem: mid pons	L	-2,26,-30	11	4.40
Dorsomedial prefrontal cortex (supplementary motor area)	L	-2,20,58	514	4.40
	R	8,12,54		4.21
	L	-8,10,56		3.88
Anterior insula	L	-44,22,-4	300	4.25
Lateral frontal pole	L	-28,56,6	398	4.22
Amygdala bilateral	L	-24,0,-20	86	4.17
	R	22,0,-18	55	3.76
Uncus/ anterior insula	R	36,10,-22,	195	4.13
Dorsolateral prefrontal cortex	L	-54,22,20	882	4.08
	R	50,16,30	222	4.07
	R	48,16,48	79	3.84
Posterior superior temporal gyrus	L	-62,-48,-4	259	4.07
Hypothalamus / substantia nigra	L	-8,-12,10	42	4.05
Lateral superior frontal gyrus	L	-26,0,62	324	3.98
Angular gyrus	L	-28,-54,52	117	3.90
Middle frontal gyrus	R	46,22,14	42	3.81
Thalamus	R	14,-12,10	41	3.7
Normoxia greater than hypoxia
No supra threshold clusters	-	-	-	-
Paced>unpaced breathing
Middle frontal gyrus	R	32,34,16	50	3.94
Unpaced>paced breathing
Mid insula	R	50,-4,0	45	3.50
Slow rate paced breathing more than normal rate paced breathing
Cerebellum (extended cluster encompassing dorsal brainstem and striatum)	L	-20,-40,-34	24014	5.94
Midbrain: periaqueductal grey		-8,26,4		4.63
Brainstem: dorsal pons		-6,-30,-30		4.20
Ventral striatum	L	-14,0,-2		4.78
	R	12,4,-4	199	4.23
Thalamus	R	18,-8,4	71	4.16
Dorsal anterior cingulate cortex	R	8,38,32	103	4.12
Temporal pole	R	38,2,-40	133	4.07
Superior frontal gyrus	R	30,2,66	7337	5.25
Superior parietal lobule	L	-54,-36,42	935	4.66
Normal rate paced breathing more than slow rate paced breathing
No supra threshold clusters	-	-	-	-
Interaction: hypoxia(normal v. slow rate)>normoxia(normal v. slow rate)
Lateral frontal pole	L	-26,58,8	350	4.44
Pre supplementary motor area	R	12,20,50	60	4.10
Cerebellum	R	42,-74,-32	45	3.72
Ventral striatum,	L	-16,6,-6	32	3.84
		16,8,-8	14	3.53
Interaction: hypoxia(slow v. normal rate)>normoxia(slow v. normal rate)
No supra threshold clusters	-	-	-	-