Table 4. Comparisons of stress-induced % changes between LVD and NLVR groups.
| Compound name and Pathway | LVD pre-stress: median (frstqrt, thrdqrt) | LVD post-stress: median (frstqrt, thrdqrt) | NLVR pre-stress: median (frstqrt, thrdqrt) | NLVR post-stress: median (frstqrt, thrdqrt) | LVD % change: median (frstqrt, thrdqrt) | NLVR % change: median (frstqrt, thrdqrt) | p-value |
|---|---|---|---|---|---|---|---|
| Tyrosine | |||||||
| Tyrosine | 84.74 (70.19, 120.45) | 79.26 (63.65, 116.05) | 102.24(75.51, 119.52) | 88.27 (73.84, 100.00) | −7.68 (−11.72, −1.33) | −14.97 (−16.33, −11.71) | 0.019 |
| 4-Hydroxyphenyllactic acid | 83.69 (61.95, 101.08) | 72.43 (64.31, 97.72) | 94.54 (85.01, 125.94) | 97.20 (82.59, 122.62) | −3.77 (−8.33, 4.61) | −3.16 (−6.30, 4.98) | 0.98 |
| 4-Hydroxybenzoic acid | 40.06 (9.95, 146.62) | 38.09 (10.13, 165.02) | 85.11 (23.85, 130.28) | 73.40 (18.37, 130.21) | −1.04 (−5.88, 5.49) | −2.80 (−10.52, 8.69) | 0.55 |
| Homogentisic acid | 65.55 (36.49, 106.78) | 64.70 (33.98, 90.91) | 69.06 (58.26, 142.48) | 60.06 (48.41, 95.34) | −8.16 (−18.46, 2.54) | −13.03 (−31.06, −8.07) | 0.18 |
| Methoxy-hydroxyphenly glycol | 86.13 (70.71, 111.06) | 85.39 (69.10, 109.17) | 98.17 (79.41, 111.51) | 100.61 (80.74, 112.65) | −.86 (−6.11, 12.76) | .88 (−5.50, 5.69) | 0.66 |
| Homovanillic acid | 81.10 (66.71, 107.29) | 87.47 (56.11, 122.33) | 73.17 (56.30, 104.77) | 71.80 (46.49, 90.62) | −8.19 (−12.15, 10.16) | −14.44 (−34.58, −7.82) | 0.10 |
| Tryptophan | |||||||
| Tryptophan | 93.54 (85.45, 102.74) | 95.40 (80.40, 99.50) | 101.52(77.12, 109.80) | 94.05 (77.90, 101.83) | −3.58 (−5.22, 0.89) | −4.19 (−11.05, −.03) | 0.29 |
| 5-Hydroxytryptophan | 1.12 (.1, 2.16) | 1.32 (.10, 1.94) | 1.07 (.10, 2.17) | 1.04 (.10, 1.98) | 0 (−10.19, 9.43) | 0 (−17.20, 3.73) | 0.88 |
| Serotonin | 79.25 (36.46, 113.71) | 82.71 (42.76, 117.70) | 74.46 (33.13, 125.41) | 87.91 (49.54, 138.47) | −.23 (−26.15, 59.87) | 10.39 (−22.65, 84.91) | 0.55 |
| 5-Hydroxyindoleacetic acid | 71.54 (47.23, 107.60) | 71.58 (49.67, 111.80) | 78.80 (57.13, 114.19) | 84.87 (63.51, 101.18) | −.97 (−19.17, 13.77) | −9.72 (−18.66, 6.03) | 0.49 |
| N-Acetylserotonin | 73.79 (62.51, 91.31) | 72.53 (60.61, 95.41) | 90.37 (78.58, 127.71) | 85.02 (74.31, 113.81) | −4.10 (−5.70, 5.50) | −6.83 (−12.58, −1.19) | 0.054 |
| Kynurenine | 98.17 (89.56, 110.16) | 92.78 (83.37, 109.83) | 100.27 (82.27, 119.22) | 94.43 (74.98, 112.77) | −3.20 (−6.05, 3.28) | −8.86 (−9.84, −1.34) | 0.036 |
| 3-Hydroxykynurenine | 76.46 (49.3, 91.79) | 67.18 (47.65, 86.83) | 113.30(79.58, 143.58) | 93.10 (68.73, 116.73) | −7.22 (−12.19, 0) | −10.29 (−22.05, −1.59) | 0.33 |
| 3-Hydroxyanthranillic acid | 2.97 (.10, 53.71) | 2.01 (.10, 45.81) | 8.08 (.10, 59.73) | 7.91 (.10, 51.30) | 0 (−9.34, 16.16) | −12.65 (−30.96, 6.42) | 0.33 |
| Indole-3-lactic acid | 76.45 (63.27, 115.03) | 69.89 (58.71, 108.56) | 89.75 (65.66, 120.44) | 79.71 (61.55, 113.56) | −7.38 (−12.63, −1.71) | −10.02 (−17.01, −5.71) | 0.15 |
| Indole-3-propionic acid | 68.35 (28.11, 83.89) | 62.32 (42.01, 80.48) | 83.03 (41.64, 208.38) | 68.12 (42.88, 185.63) | −1.07 (−8.75, 19.35) | −3.60 (−11, 2.39) | 0.60 |
| Purine | |||||||
| Hypoxanthine | 70.85 (59.75, 89.01) | 86.17 (55.21, 103.74) | 80.44 (55.43, 88.94) | 94.08 (73.49, 111.91) | −.86 (−20.76, 47.74) | 17.32 (8.29, 33.26) | 0.35 |
| Xanthine | 91.54 (71.10, 119.54) | 90.81 (70.18, 117.18) | 78.64 (69.74, 99.44) | 80.37 (67.05, 93.48) | −1.34 (−12.29, 11.33) | 1.17 (−5.43, 13.53) | 0.44 |
| Uric acid | 96.50 (87.83, 102.64) | 96.20 (86.32, 103.92) | 93.65 (90.10, 104.11) | 89.70 (87.01, 103.10) | .54 (−1.72, 1.35) | −2.42 (−6.93, −.54) | 0.015 |
| One-carbon metabolism | |||||||
| Methionine | 91.79 (71.75, 110.43) | 86.92 (71.26, 99.41) | 103.06 (80.28, 133.27) | 85.54 (71.13, 110.84) | −8.71 (−16.28, −2.77) | −13.83 (−23.00, −10.25) | 0.065 |
| Tocopherol | |||||||
| Tocopherol-gamma | 85.52 (34.68, 112.42) | 81.72 (27.76, 109.30) | 37.31 (22.46, 57.01) | 34.26 (17.29, 48.77) | −13.61 (−27.31,4.37) | −6.01 (−41.30, 17.19) | 0.73 |
| Tocopherol-alpha | 78.39 (73.45, 86.25) | 67.95 (39.86, 83.69) | 58.59 (33.22, 69.64) | 48.37 (25.75, 99.25) | −16.34 (−30.24, 10.46) | 3.40 (−35.13, 21.96) | 0.44 |