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Cellular miRNAs targeting HCV genome. The binding of two copies of miR-122 within the 5′ UTR of the HCV genome enhances viral replication and translation. The binding of miR-199a at 5′UTR inhibits viral replication. Let-7b interacts with viral genome at two different locations, 5′UTR and NS5B coding region. miR-448 targets Core and miR-196 targets NS5A of the HCV genome. miR-181c inhibits viral replication by targeting E1 and NS5A regions of viral genome.
