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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Jul 19;91(15):6963–6966. doi: 10.1073/pnas.91.15.6963

A scheme for sequencing large DNA molecules by identifying local nuclear-induced effects.

I Kelson 1, S Nussinov 1
PMCID: PMC44318  PMID: 8041730

Abstract

An experimental scheme for sequencing large DNA molecules is proposed where DNA strands are replicated, with all nucleotides of a given kind marked with radioactive 32P. The marked strands are affixed to an appropriate substrate and are kept until most 32P atoms decay. The local damage caused by the decay is expected to allow the identification of the sites occupied by that particular nucleotide, using atomic scale microscopy (scanning tunneling or atomic force microscopy). Quantitative aspects and methodological considerations associated with the proposed scheme are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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