Table 3. Association between the intradialytic change in the putative stimuli and the change in plasma copeptin levels during hemodialysis.
| Determinants | Multivariate linear regression | |||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | |||||||
| B | Betastandardized | CI | P-value | B | Betastandardized | CI | P-value | |
| Δ sodium (mmol/l) | -0.028 | -0.010 | -0.157; 0.100 | 0.66 | -0.003 | -0.001 | -0.157; 0.150 | 0.9 |
| Δ MAP (mmHg) | -0.025 | -0.083 | -0.045; -0.005 | 0.02 | -0.015 | -0.051 | -0.030; 0.000 | 0.04 |
| Δ RBV (%) | -0.049 | -0.050 | -0.085; -0.014 | 0.01 | -0.057 | -0.057 | -0.098; -0.016 | 0.01 |
Model 1: adjustment for age, sex, diabetes and predialysis copeptin levels.
Model 2: as model 1 and additionally adjusted for the other determinants included in this model.
Δ: from predialysis to postdialysis for sodium and RBV, for predialysis to 210 minutes intra-dialysis for MAP, with correction for predialysis sodium and predialysis MAP.
Abbreviations: CI: confidence interval of B; MAP: mean arterial pressure; RBV: relative blood volume.