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. 2015 May 14;11(5):e1005233. doi: 10.1371/journal.pgen.1005233

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© 2015 Castelli et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — A. Active translation. Short mRNA (blue line with grey ORF) shown with eIF4E (purple) bound to 5’cap (blue), eIF4G (blue oval) and Pab1p (green oval) facilitating mRNA circularisation and ribosome recruitment (cream ovals) that excludes Caf20p binding eIF4E. B. Caf20p mediated eIF4E-dependent translational repression. eIF4E/4G/Pab1p closed loop unstable on long mRNAs facilitating Caf20p binding (red). Caf20p binding to 80S ribosomes may contribute to its local recruitment. C. 4E-IND repression mechanisms. Caf20p 3’ UTR motif binding (may not be direct), either alone or in addition to 80S binding facilitates translational repression. eIF4E-Caf20p binding may contribute to repression on some of these mRNAs.