Table 3. Genes showing ≥3-fold differences in expression level in IgG4-RD patients and healthy controls.
| Transcripts Cluster Id | Regulation | Gene symbol | Gene description |
|---|---|---|---|
| * 8036755 | down | CLC | Charcot-Leyden crystal protein |
| 8022728 | down | DSC1 | desmocollin 1 |
| * 8058905 | down | IL8RA | interleukin 8 receptor, alpha |
| * 8048227 | down | IL8RB | interleukin 8 receptor, beta |
| 8135488 | down | LRRN3 | leucine rich repeat neuronal 3 |
| 7981708 | up | IGHE | immunoglobulin heavy constant epsilon |
| 8095736 | up | AREG|LOC727738 | amphiregulin (schwannoma-derived growth factor) |
| 8095744 | up | AREG|LOC727738 | amphiregulin (schwannoma-derived growth factor) |
| 8101322 | up | MOP-1 | |
| 8055952 | up | NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| 8156848 | up | NR4A3 | nuclear receptor subfamily 4, group A, member 3 |
| 8012349 | up | PER1 | period homolog 1 (Drosophila) |
| 7908388 | up | RGS1 | regulator of G-protein signaling 1 |
| 8005547 | up | SNORD3A | small nucleolar RNA, C/D box 3A |
| 8005553 | up | SNORD4A | small nucleolar RNA, C/D box 4A |
| 8013323 | up | SNORD5A | small nucleolar RNA, C/D box 5A |
| 8013325 | up | SNORD6A | small nucleolar RNA, C/D box 6A |
| 8013329 | up | SNORD7A | small nucleolar RNA, C/D box 7A |
| 7922416 | up | SNORD75 | small nucleolar RNA, C/D box 75 |
| 7982597 | up | THBS1 | thrombospondin 1 |
| 8116992 | up | UNQ9364 | FLFF9364 |
We identified 21 genes showing a ≥3-fold increase (16 genes) or decrease (5genes) in expression level among 4 samples from 4 healthy controls and 2 IgG4-RD patients before and after therapy.
*processed to the validation.