Table 5. The list of disease-associated genes using K-means clustering.
| Transcripts Cluster ID | Gene symbol | Gene description |
|---|---|---|
| * 7940216 | MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) |
| 7946033 | HBB | hemoglobin, beta |
| 7948444 | TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
| 7951246 | MMP8 | matrix metallopeptidase 8 (neutrophil collagenase) |
| 7969288 | OLFM4 | olfactomedin 4 |
| 7973105 | RNASE3 | ribonuclease, RNase A family, 3 (eosinophil cationic protein) |
| 7978351 | CTSG | cathepsin G |
| 7991762 | HBA1|HBA2 | hemoglobin, alpha 1 | hemoglobin, alpha 2 |
| 7991766 | HBA1|HBA2 | hemoglobin, alpha 1 | hemoglobin, alpha 2 |
| 7995237 | ERAF | erythroid associated factor |
| 8015991 | SLC4A1 | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) |
| 8016932 | MPO | myeloperoxidase |
| 8021645 | SERPINB10 | serpin peptidase inhibitor, clade B (ovalbumin), member 10 |
| 8029098 | CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| 8037222 | CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 |
| 8037298 | LOC100130904 | similar to CD177 molecule |
| 8062444 | BPI | bactericidal/permeability-increasing protein |
| 8066493 | SLPI | secretory leukocyte peptidase inhibitor |
| 8086607 | LTF | lactotransferrin |
| 8122058 | ARG1 | arginase, liver |
| 8126905 | CRISP3 | cysteine-rich secretory protein 3 |
| 8145281 | SLC25A37 | solute carrier family 25, member 37 |
| 8145291 | SLC25A37 | solute carrier family 25, member 37 | hypothetical protein LOC100133914 |
| * 8149109 | DEFA4 | defensin, alpha 4, corticostatin |
| 8149116 | DEFA1 | defensin, alpha 1 defensin, alpha 3, neutrophil-specific |
| 8149126 | DEFA1 | defensin, alpha 1 defensin, alpha 3, neutrophil-specific |
| * 8149137 | DEFA3 | defensin, alpha 3, neutrophil-specific defensin, alpha 1 |defensin, theta 1 pseudogene |
| 8151592 | CA1 | carbonic anhydrase I |
| 8173135 | ALAS2 | aminolevulinate, delta-, synthase 2 |
| 8177222 | CD24 |
K-means clustering was used for statistical processing of disease-associated genes, we identified 30 genes. All genes had increased expression level by steroid therapy.
*processed to the validation.