Table 2. Associations of moderate-to-vigorous physical activity (MVPA) and sedentary time with markers of insulin sensitivity.

	HOMA-IS		Matsuda-ISI
	β	P	β	p
Model 1
MVPA	1.17 (1.09, 1.26)	<0.001	1.28(1.17, 1.40)	<0.001
Sedentary	0.94 (0.92, 0.97)	<0.001	0.91 (0.89, 0.94)	<0.001
Model 2
MVPA	1.11 (1.01, 1.22)	0.040	1.17(1.03, 1.31)	0.012
Sedentary	0.97 (0.93, 1.00)	0.084	0.95 (0.91, 0.99)	0.017
Model 3
MVPA	1.04 (0.95, 1.15)	0.267	1.13 (1.00, 1.26)	0.048
Sedentary	0.98 (0.95, 1.02)	0.351	0.96 (0.92, 1.00)	0.043

Coefficients represent the factor by which the measure of insulin sensitivity is multiplied by (95% Confidence Interval) for a 30 minute difference in sedentary time or MVPA

Model 1 adjusted for age, sex, ethnicity, smoking status, statin medication status, beta-blocker status and accelerometer wear time

Model 2 adjusted for above variables plus MVPA (for the sedentary time model) or sedentary time (for the MVPA model)

Model 3 adjusted for the above plus BMI