Fig 18. Effects of different inhibition ranges of secreted factors in negative feedback loop to stem cells on tissue size control.

Examples of tissue pattern and the time course of population size of different cell types when stem cells are inhibited by differentiated cells located within (a,d) 3-, (b,e) 2-, and (c,f) 4-layers of neighboring cells, respectively. Normal size control with the ability to regenerate is achieved when 3 layers of neighboring cells are inhibited (a, and d). When 2 layers of cells are inhibited, size control is no longer possible (b and e). When 4 layers of cells are inhibited, tissue size is suppressed.